الفهرس 
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Abstract
The master thesis include aim of the work and Three main chapters
I- Aim of the work
The work aimed to prepare and characterize ligand (E)-2-
((aminobis(Phenylamino)methyl)imino)-1,2diphenylethanone
derived from the condensation of benzil with appropriate
aromatic amine and its metal complexes aiming to study their
effects in the treatment of tumor diseases .
II- Introduction
This chapter includes an overview of previous researches for
complexes of ligands and their application.
III- Experimental
This chapter contains the chemical and instruments used in
Practical part of thesis as follow:
1) Preparation of the ligand(E)-2-((amino bis(Phenyl
amino)methyl)imino)-1,2-diphenylethanone
derived from the condensation of benzil with
appropriate aromatic amine and its metal
complexes.
2) characterization of the ligand and its complexes using:
Physical techniques such as molar conductance and magnetic
susceptibility
Elemental analysis (C, H, N, Cl and M).
Spectral techniques as IR, UV- Vis., 1HNMR, mass spectra
and ESR measurements.
Thermal techniques as DTA. and TGA
3) Measurement of biological activity
iv. Results and discussion
This chapter includes characterization of the ligand and its complexes.
The ligand (E)-2-((amino bis(Phenyl amino)methyl)imino)-1,2-
diphenylethanone was prepared as follow:
1- Condensation of aniline with Thiourea (2:1) for Three hours to
obtain N,N\ -diphenylmethantetraamine.
2- Condensation of N,N\ -diphenylmethantetraamine with Benzil for
Eight hours to obtain The ligand (E)-2-((amino bis(Phenyl
amino)methyl)imino)-1,2-diphenylethanone.
The reaction of the ligand with Cu(II), Ni(II), Mn(II), Fe(III), Co(II),
Zn(II), Cd(II) and Pb(II), complexes have been synthesized and characterized
by (1H-NMR, mass, IR, UV-VIS, ESR) spectroscopy, (magnetic moments,
conductance) measurements, (elemental and thermal) analyses. The IR
spectral data show that, the (E)-2-((amino bis(Phenyl amino)methyl)imino)-
1,2-diphenylethanone behaves as a neutral bidentate ligand bonded to the metal ions through the azomethine nitrogen atom and oxygen atom in Ketone
adopting octahedral geometry.
Molar conductance in DMF solution indicates that, the complexes are
non-electrolytes .
ESR spectra of solid copper(II) complexes (12), (18) and (22) (Table
6), showed that, the complexes exhibited anisotropic signals with g values,
g= 2.19, 2.15 and 2.21 and g values are 2.09 , 2.0 and 2.08 respectively.
These values are characteristic for a species with d9 configuration with an
axial symmetry type of d(x
2
-y
2
) ground state. The g > g> g e (2.0023)
indicating that, the complexes possessed a tetragonal distortion copper(II) ion
corresponding to an elongation along the four fold symmetry z-axis,
Complexes (3), (4), (9), (23) and (24) show isotropic spectra with giso= 2.05,
2.008, 2.1, 2.01and 2.07respectively
. Cytotoxic evolution of the ligand and its complexes have been carried
out. Complexes show enhanced activity in comparison to the parent ligand.
Metal complexes (2), (3), (4), (5), (6), (7), (11) and (21) were evaluated
against HEPG-2 cell line chemotherapeutic effect against HEPG- 2 cell line
than the standard drug used. Also, the Mn(II) complex (4) shows the highest
potency of inhibition at 50 µg/ml against HEPG-cell lines, compared with the
standard drug.