الفهرس 
: Sleep among the elderlyOnly 14 pages are availabe for public view
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Abstract
Objective: The current study was conducted to assess disturbance in sleep pattern in patients with AD, and compare it to cognitively healthy elderly individuals. The study included 20 patients with AD with mean age 66.05 ± 2.04 and 20 healthy elderly subjects with mean age 65.25 ± 2.22.
Method: All participants undergone, a full medical, neurological, psychiatric history and clinical examinations, Lab tests (complete blood picture, liver function tests and thyroid profile) and CT scan or MRI brain. For each subject the MMSE was used to provide a simple global measure of cognitive functioning and CDR was used to stage the degree of global severity, the Geriatric Depression Scale (GDS), The Cornell Scale for Depression in Dementia and Taylor Anxiety Scale for excluding patients with depression and anxiety. All patients were subjected to Overnight PSG recordings and psychometric sleep assessment (an Arabic version for sleep evaluation of the Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI)).
Results: This study showed abnormal subjective sleep quality in all patients and poorer sleep efficiency, prolonged sleep latency and a tendency for more wake after sleep onset high (AI) with highly significant statistical difference of both groups. Moreover, patients spent more time in stage I & II sleep, and had less time in SWS and REM sleep compared to control populations, and delayed REML and more REMD. The results of this study showed no statistical significant difference of as regards sleep parameters (PMLs index and respiratory events) for both control and patient groups. Also, we found no statistical difference as regards sleep parameters (SE, SL, SWS and AI) and grade of dementia assessed by cognitive scoring tests; MMSE and CDR in patient group. This current results showed no statistical significant difference as regards sleep parameters (SE, SL, SWS and AI) and subjective sleep assessment (PSQI) and degree of cerebral atrophy (CT/MRI brain) in patient group.
Conclusion: The current study confirms that sleep is significantly impaired in patients with AD at both the objective by PSG recordings and subjective level. Also this study suggests a role of PSG in diagnosis of AD.