الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 128 |  |  |
| | | from | 128 | | |
Abstract
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels. According to International Diabetes Federation (IDF), at least 371 million people have diabetes worldwide in 2012, which is predicted to be 552 million by 2030 .Of all the diabetic cases, 90-95% of them suffer from type 2 diabetes (T2D). Unlike type 1 diabetes (T1D), which is denoted as diminished insulinproduction, T2D is a heterogeneous disorder characterized by impaired cellular responses to insulin known as insulin resistance and followed by progressive partial pancreatic β-cell dysfunction.
Mulberry belongs to the genus Morus of the family Moraceae, Mulberry shown to have potent glucosidase inhibitory activity mainly because of its azasugars. This has led to the acceptance that mulberry intake is beneficial for attenuating postprandial hyperglycemia, that may prevent diabetes. To date, there are several studies have been conducted concerning with mullberry.
This work designed to investigate the effect of the alcoholic extract of mulberry leaves in STZ-diabetic rats for this, the following parameters were determined:A. Fasting Blood Glucose (FBS), Glycated hemoglobin (HbA1C),Serum insulin, Lactate, Pyruvate and LDH activity B. Moreover, the gene expression of the related liver enzymes & glucose.