الفهرس 
Cardiovascular diseases
Alternative medicine overviewOnly 14 pages are availabe for public view
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Abstract
Hypercholesterolemia has been implicated in causation
of coronary heart disease. Ginkgo biloba has been used in some
countries as a hypolipidemic agent. Accordingly, this study
aimed to study the effect of different doses of Ginkgo biloba
extract (GBE) on lipid profile, liver and kidney functions in
hypercholesterolemic rats. Forty eight rats were divided into six
groups. The first group was fed on standard diet only as
negative control. Second group was fed on
hypercholesterolemic diet as positive control. The other four
groups were fed on hypercholesterolemic diet for four weeks to
induce hypercholesterolemia, then these groups were fed on
standard diet and orally administrated different levels of GBE
(25, 50, 75 and 100 mg/kg B.W/day) for 28 days. Also GBE
was applied in functional food by making biscuits fortified with
this extract with the four doses (25, 50, 75 and 100 mg/kg) used
in this experiment. Results showed that using four levels of
GBE in treating hypercholesterolemic rats led to significant
improvement in lipid profile. Levels of 50, 75 and 100 GBE
mg/kg B.W induced significant decrease in serum triglycerides
III
and cholesterol in hypercholesterolemic groups, as compared to
positive control and GBE 25 mg/kg B.W groups. All treated
groups with different levels of GBE produced an improvement
in serum ALT, AST, uric acid and creatinine levels, as
compared to positive control group. Histological examination
of liver tissues indicated progress in morphological changes
occurred in hypercholesterolemic rats via ingestion of GBE. It
was found that biscuits supplemented with 25 mg of GBE then
sample supplemented with 50 mg of GBE tended to have the
best taste and overall acceptable among all supplemented
samples. So it can be recommended to consume biscuits
fortified with 50 mg of GBE for their health benefits and
acceptability by panels.