الفهرس 
Congenital Heart Diseases (CHDs)Only 14 pages are availabe for public view
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Abstract
Congenital heart disease (CHD) is the most common type of malformations which may be a solitary defect that can close spontaneously as in small VSD, but may be a complex disorder causing early death. Although there is progress in diagnosis, medical and surgical treatment , neurological injury remains the most prevalent complication after cardiac surgery.Patients undergoing cardiac surgery with cardiopulmonary bypass(CPB) are at risk for neurological injury during anesthesia, CPB phases and postoperative period; mainly due to cerebral ischemia. S100B protein is a calcium binding protein found in intra and extracellular brain tissue. Its detection in the blood indicates brain damage and /or reduced integrity of the blood brain barrier. It is widely used as a research biomarker to study brain injury. Some studies have shown that the blood concentration of S100B protein predicts volume of infarct and neurological outcome following ischemic brain injury.The objectives of the present work were to evaluate the serum levels of S100 B protein as a diagnostic marker of perioperative brain injury in infants with CHD undergoing cardiac surgery, and to evaluate the prognostic value of S100 B protein, by correlation of its levels with neurodevelopmental outcomes in those cardiac patients.