الفهرس 
AbstractOnly 14 pages are availabe for public view
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Abstract
Periodontitis is a chronic inflammatory infection in which tissue destruction is associated with an imbalance between oxidant-antioxidant systems. Melatonin is an indoleamine that has antioxidant actions. Nonsurgical treatment is one of periodontal treatment methods that affects etiologic factors. This study investigated salivary and serum melatonin concentration in generalized severe chronic periodontitis patients and in individuals with healthy periodontium and their changes following nonsurgical periodontal therapy. The aim of this study was to evaluate the effect of non-surgical periodontal therapy on salivary and serum melatonin levels in patients with chronic periodontitis. And to find the possibility of use melatonin as a diagnostic biomarker for periodontal disease. Melatonin was decreased in saliva of severe generalized chronic periodontitis patients when compared to the healthy individuals. Salivary melatonin level was recovered after non-surgical periodontal therapy. This may imply the local involvement of melatonin in the pathogenesis of periodontitis due to its antioxidant abilities. Salivary melatonin could be used as a diagnostic biomarker for the periodontal disease severity.