الفهرس 
GENERAL INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Thesis title: Porous multiparticulate systems for tailoring pharmaceutical performance of some drugs
This thesis aims to investigate multiparticulate porous particles as promising drug delivery systems. Despite the increase in the number of studies addressing these porous drug delivery systems throughout the last decade, these systems are not a novelty to the drug delivery community. In fact, they have been present and considered in Higuchi’s equations that laid grounds to modern pharmaceutics in the 1960s. yet, the focus on porous materials as drug delivery systems began to actualize in the late 1980s. Today commercial porous drug delivery systems continue to expand and evolve in terms of drug delivery route and target.
Porous drug delivery systems can be prepared with a variety of materials, the most important and common are polymers and silicates. This thesis is thus concerned with the preparation, optimization and characterization of multiparticulate porous drug delivery systems, based on either Eudragit RS-100 or silicates.
Part I:
Title:” Polymeric Microsponge: investigation of impact of different formulation variables on product characteristics and its oral drug delivery potential”
where this part is divided into two chapters:
Chapter 1:
Title: Preparation and characterization of blank Eudragit RS-100 Microsponge
Microsponge are a type of solid state, matrix type, porous polymeric microspheres. They are of a wide current application in topical drug delivery and cosmeceuticals, while their oral drug delivery applications are still juvenile and research bound. This part was concerned with the preparation, optimization and characterization of blank Eudragit RS-100 based Microsponge by o/w emulsion based spherical agglomeration technique, and studying the effect of seven different formulation variables on the characteristics of the resultant sponge aiming at establishing a reference work for tailoring the properties of microsponge to its drug delivery application of purpose. The seven investigated formulation variables were: Eudragit RS-100 (matrix former) concentration in organic phase, Polyvinyl alcohol (stabilizer) concentration in aqueous phase, triethylcitrate (plasticizer) concentration relative to matrix former, diffusing solvent type, bridging to diffusing solvent ratio, aqueous to organic phase ratio, stirring rate.