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Abstract Urinary tract infection is one of the most common hospitalacquired infections; 70%–80% of these infections are due to an indwelling urethral catheter. Outcomes associated with CAUTI are infection, which is the most important adverse outcome, then nonbacterial urethral inflammation, urethral strictures, mechanical trauma, mobility impairment, secondary bloodstream infection, death, and increased health care costs. Proteus spp, members of the family Enterobacteriaceae, are motile Gram negative enteric bacteria; they are important pathogens of the urinary tract and are the primary infectious agent in patients with long term indwelling urinary catheters. Those pathogenic bacteria have developed numerous virulence factors to adapt to their host environment, studying the main Proteus spp virulence factors would increase our understanding of how a microorganism from normal flora infects and colonizes other sites and establishes infection. >Accordingly, the aim of this work was to isolate Proteus spp from patients had CAUTI and study some of virulence factors expressed by these organisms allowing them to cause UTI and determine the pattern of their sensitivity to different classes of antibiotics. This study carried on 110 urine specimens taken from indwelling urethral catheters of patients suffering from UTI symptoms, under complete aseptic technique then submitted to the laboratory of Microbiology and Immunology Department in Faculty of Medicine, Tanta University during the period from January 2015 until the end of October2015 for routine cultures for detection of the causative organism. |