الفهرس 
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Abstract
CD is one of the most frequent autoimmune disorders occurring in T1DM. The clinical presentation of CD in T1DM is classified as symptomless in approximately half of cases, but a more accurate analysis often discloses a wide array of symptoms suggestive of CD. Both T1DM and CD show the same genetic background and an abnormal small intestinal immune response with inflammation and a variable grades of enteropathy.
Aim of the study:
The aim of this study is to determine the prevalence of celiac disease in type1 diabetic patients using serum tissue transglutaminase IgA antibody as screening test and study the clinical profile of these patients.
Patients and methods:
The current study is cross sectional case-control study included 90 persons that were divided into two groups; 75 patients with type 1 Diabetes Mellitus (41 females & 34 males), there ages range from 9 to30 years, and 15 persons (age and sex matched healthy volunteers) as normal control (with no family history of diabetes mellitus) were taken from the Outpatient Clinic of endocrine and metabolism at Minia university Hospital, in the period from March 2014 to November 2014.
All patients and controls were subjected to:
A-Full history taking. B-Clinical Examination with stressing on the following: C- Laboratory investigations: 1- Blood samples for: routine lab. Investigations (CBC. HbA1c. Renal functions, liver enzymes, lipid profile, FPG and PPG) and special investigations (Detection of IgA tissue transglutaminase antibodies in serum by enzyme linked immunoabsorbent assay ELISA).
2- stool analysis
D- statistical analysis: The data were coded, entered and processed on an IBM-PC compatible computer using SPSS (statistical program for social science version 19).
The study revealed that:
Out of 75 diabetic patients studied, 4 patients (5.3%) were positive for IgA Tissue Trans-glutaminase antibody and 71 patients (94.7%) were negative.
These results showed that Sero +ve cases had a significant predominance of female gender as from 4 patients with sero +ve, 3 patients (75% of them) were females.
The sero +ve diabetic patients were exposed to gluten at an early age than sero –ve as mean time of gluten introduction was 4.5 ± 1 months in sero +ve versus 7.1 ±2.4 months in sero-ve group which had statistically significant difference between the two groups (p=0.023).