الفهرس | Only 14 pages are availabe for public view |
Abstract Background: There is accumulating evidence that inflammation can cause seizure and seizure can cause brain inflammation perpetuating antiepileptic drug refractoriness in patients with epilepsy. Aim of the study: This study is designed to evaluate IL-1β in the sera of patients with new onset epilepsy (less than 8-month duration) vs. patients with chronic epilepsy (more than 8-month duration) to explore its importance and the proper time for potential targeting of this pathway. Patients and Methods: Fifty-six patients with idiopathic generalized epilepsy were included in the study during their hospitalization for seizure management and their interleukin -1beta were assessed within 12-hours of the index seizure by ELIZA (Enzyme Linked Immunosorbent Assay). Another assessment was done in 20 patients after 24-hours of the index seizure. Results and Conclusion: Interleukin-1beta was increased significantly within 12-hours and dropped significantly in the twenty patients after 24-hours of the index seizure (P<0.001*). The 24-hours assay is still significantly higher than normal population (P=0.003*). This increased was not significantly different by seizure frequency, number of antiepileptic drugs or duration of epilepsy. We Concluded that Seizures do increase interleukin-1beta and the later might have a role in seizure generation in idiopathic generalized epilepsy. |