الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 106 |  |  |
| | | from | 106 | | |
Abstract
This is a descriptive study, which included all neonates admitted with clinically significant jaundice between January 2010 and December 2012 at Minia University Hospital. It included 453 neonates fulfilled inclusion criteria for this study. Cases were identified from the neonatal unit log books; however, on review of the individual charts, any case that did not require medical intervention was excluded. Demographic, clinical and laboratory data were collected.
This study aimed to assess the frequency and causes of significant neonatal jaundice at NICU of Minia University Hospital over a three year period (from January 2010 to December 2012), and to determine the relation between neonatal jaundice and sex, gestational age, gravidity of mother, mother educational level, residence, feeding condition and type of delivery and to formulates measures of prevention, early detection and management of significant neonatal jaundice, thereby reducing the disease burden in the community. Descriptive analyses were performed.
The results were concluded as:
1. Frequency:
The frequency of clinically significant neonatal jaundice was 453 neonates (45.9%) from 987 live births admitted at Minia University Hospital during the study period.
2. Demographic data of mothers and infants:
Demographic data of mothers and infants were 57.8% of cases were males, the male/female ratio was 1.37. Rural neonates represent 74.4% of all cases. The majority of the mothers (67.7%) were primiparous. 66.9% of infants had exclusive breast feeding. About mother educational level in our study, literate mothers were 341 (75.3%) and illiterate mothers were 112 ones (24.6%).
3. Admission characteristics of neonates:
Admission characteristics were as follows, neonates with unconjugated hyperbilirubinaemia represent 91.2%, preterm infants were 57.6%. The mean age of presentation at the hospital was 6.8 days. The mean of onset of jaundice (days) ± standard deviation, (range) was 2.89 ± 3.5 (1-28). The mean ± SD day of life of peak bilirubin level was 4.7 ± 2.1. Regarding season of admission, hot weather (summer and spring) represent (66.5 %). There were 53 (11.6%) dehydrated infants. There were five cases with signs of acute bilirubin encephalopathy at the time of hospital admission.
4. Etiology of clinically significant unconjugated hyperbilirubinaemia in neonates (causes):
The etiology of significant jaundice in the neonates was attributed to prematurity in 193 (42.6%), ABO incompatibility in 86 (19.0%), infection in 51 (11.3%), exclusive breast feeding in 18 (4.0%), Rhesus incompatibility in 14 (3.1%), infant of diabetic mother in 7 (1.5%) and no cause was identified in 73 (16.1%) infants. There was no screening for G6PD deficiency.
5. Treatment of clinically significant unconjugated hyperbilirubinaemia in neonates:
All infants received phototherapy but 95 cases (23.0%) needed exchange blood transfusion with phototherapy.
6. The relation between causes and cases needed exchange blood transfusion and phototherapy in studied cases:
The results illustrated that 55.8% of all cases with ABO incompatibility, 78.57% of all cases with RH incompatibility, 4.66% of all cases with prematurity, 17.64% of all cases that presented with sepsis and 24.66% of all cases who presented with undetermined causes, needed exchange blood transfusion and phototherapy.