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العنوان
SYNTHESIS OF NEW QUINOLONES SUBSTITUTED WITH DISCREPANT HETEROCYCLES\
المؤلف
HASSANIEN, HANY MOHAMED MOHAMED.
هيئة الاعداد
باحث / HANY MOHAMED MOHAMED HASSANIEN
مشرف / El-Hossain Ali Mohamed
مشرف / Mostafa Mohamed Ismail
مشرف / Elham Sayed Othman
الموضوع
i) a, -unsaturated carbonyl quinolinones ii) -ketoester and a,y-diketoester<br>iii) pyrazoloquinolines<br>iv) isoxazoloquinolines
تاريخ النشر
2002
عدد الصفحات
202P.:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكيمياء
تاريخ الإجازة
1/1/2002
مكان الإجازة
جامعة عين شمس - كلية التربية - Chemistry
الفهرس
Only 14 pages are availabe for public view

from 202

from 202

Abstract

3-Acetyl-l-ethyl-4-hydroxyquinolin-2(1H)-one (2) and l­ ethyl-4-hydroxyquinolin-2(1H)-one (3) were prepared and subjected to several and different chemical transformation aiming ·to synthesize novel quinolinone derivatives, which may have important biological activity. Compound 2, 3 were used to obtain a, -unsaturated carbonyl quinolinones (6a,b),
-ketoester 7 and a;y-diketoester 8 which, were used as an alternate precursor to produce many new five membered heterocycles as pyrazolyl, isoxazolyl, pyrazolotriazinyl, oxadiazolyl, pyrazolopyridazinyl as substituents to the quinolinone moiety. All the structures of the new products were identified on basis of their chemical behaviour, elemental and spectral analysis.