الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Rheumatoid vasculitis is the most serious systemic disease manifestation of Rheumatoid arthritis where it manifests almost exclusively in rheumatoid patients with rheumatoid autoantibodies and often occurs in the context of other extra-articular manifestations. It is defined as: a clinicopathological manifestation of RA characterized by tissue damage or ischemia verified pathologically by vasculitis.
The aim of this study was to study nailfold capillaroscopic abnormalities and serum IL-17 pattern among rheumatoid arthritis patients with or without vasculitis. Also, to evaluate the predictive value of nailfold capillaroscopic abnormalities and serum IL-17 for early detection of rheumatoid arthritis patients who are candidate for rheumatoid vasculitis.
A group of Egyptian patients with rheumatoid arthritis (n=40) diagnosed by the ACR/EULAR 2010 criteria and a group of healthy control (n=20) were all subjected to demographic data collection, clinical examination, DAS 28 calculation, laboratory measurement including ESR, CRP, RF, ANA, ANCA, Anti CCP, and IL17, and nailfold capillaroscopic examination. In addition, clinically proved vasculitic patients included in the patients (n=6) were further subjected to electrophysiological evaluation.
IL-17 showed statistically significant difference where it’s serum was higher in RA patients with nailfold capillaroscopic changes (gp1). Also, a positive relation was found between serum IL-17 and NC changes.
This study concluded that IL-17 serum level and nailfold capillaroscopy are linked to rheumatoid vasculitis.