الفهرس 
Anatomy and Physiology of the CervixOnly 14 pages are availabe for public view
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Abstract
This is a prospective studyconducted atAin
ShamsUniversity Hospital, Maternity department, to study
the effect and safety of HBBon the duration of the first stage
of labor in primigravidae (active phase of first stage labor).
The study was done through the period from July 2015 till
January 2016.
The study was conducted to 138women, 69women
received 40mg HBB slowly iv (HBB group), and
69women for received 2 ml saline (placebo group).
The inclusion criteria were: term uncomplicated
singleton pregnancy in a spontaneous active labor, with
cephalic presentation. The patient must be free from any
medical disorder associated with pregnancy and free from
any obstetric complication.
Cases were randomly allocated into two groups:
Control groupreceived two ml of saline for
injection (placebo).
HBB group received two ml (40 mg) Hyoscine-nbutylbromide
intravenously.Every patient was subjected to:
Complete history taking, general examination of the
patients, obstetric abdominal examination and vaginal
examination included cervical dilation, effacement and
position, state of fetal membranes, presenting part, position
of fetal head, color of liquor and pelvic adequacy.
A single dose of drug HBB 40 mg or placebo by
direct slow IV injection.
Pelvic examination was performed every one hour.
(to detect the progress of labor).
If membrane was intact, amniotomy was performed
when obtained regular 3 uterine contractions/10 mints.
Progress was again assessed at one hour.
When contraction is not optimal, oxytocin infusion
was started and adjusted until three to four uterine
contractions were noted in a ten-minute period and each
contraction lasts for 30-45 seconds.
The duration of the first stage of labor was
determined. It was calculated from the time of cervical
dilatation of >3 cm in active labor (Time of administration
of study drugs) until a fully dilated cervix was observed
upon vaginal examination conducted every hour.The results revealed significant reduction in the time
elapsed from injection of the drug to delivery in study HBB
group with mean 2.96 hours (177.8 minutes) than in control
(placebo) group with mean 4.03 hours (241.6 minutes)
(p<0.001). The use of oxytocin is decreased among HBB
group in comparison to control group (p value <0.001).
These results observed without significant side
effects on neonates or mothers and also no significant
difference in mode of delivery as 2 womenin HBB group
delivered by C.S. and 5 women in control group delivered
by C.S.