الفهرس 
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Abstract
Several clinical studies have suggested a possible link between chronic hepatitis caused by hepatitis C virus (HCV) infection and the development of diabetes mellitus (Mason and Nair, 2003).
The pathogenic mechanisms causing DM in patients with HCV infection are not well understood, although both insulin resistance and impaired insulin resistance and impaired insulin secretion have been considered to play an important role in the development of diabetes.
This study included 55 chronic hepatitis C patients confirmed by PCR. According to the results of their OGTT, they were divided into 3 groups: group impaired OGTT and group (C ) included 25 patients with DM. In addition, 10 healthy subjects were selected as control group.
The following investigations were done for the studied groups:
- Serum glucose levels.
- Liver enzymes ( AST, ALT).
- Serum cholesterol, triglycerides LDL and HDL.
- Serum insulin.
The following indices were calculated for each subject:
- HOMA-R.
- HOMA-B.
In the present study, both ALT and AST were elevated in the three studied group when compared to the control group. Serum triglyceride levels were significantly lower in HCV patients with diabetes and serum cholesterol level showed insignificant changes in the diseased group in comparison to the control group. HDL was higher in HCV group with DM compared to control group with statistically significant difference (p≤0.001).
LDL was lower in HCV group with DM and impaired OGTT compared to control group with statistically significant difference (P≤0.001).
The insulin resistance was measured by the homeostatic model assessment of insulin resistance (HOMA-R) .HOMA-R in CHC patients with diabetes was significantly higher than those with both normal and impaired glucose tolerance.
Insulin resistance increased with the development of glucose intolerance.
The β-cell function was assessed by the homeostatic model for assessment of β-cell function (HOMA-B
HOMA-B was significantly lower in diabetic group when compared to other diseased group. Also, there was a significant decrease in HOMA-B in impaired and normal OGTT group when compared to the control group. HOMA-B decreased in CHC patients with glucose intolerance.
HCV as metabolic disease associated with many metabolic abnormalities include DM, Hepatic Steatosis and abnormalities in lipid metabolism.