الفهرس | Only 14 pages are availabe for public view |
Abstract Background: Adiponectin is a protein hormone secreted exclusively by adipocytes that regulate the metabolism of lipids and glucose. Adiponectin has antidiabetic, antiatherogenic and anti-inflammatory properties. In addition it has an important protective role in carcinogenesis OBJECTIVE: To asses adiponectin serum levels in adolescent boys with type 1 diabetes mellitus and to study the relationships between serum adiponectin levels with pubertal development body mass index, testosterone, sex hormone binding globulin and glycemic control. Research design and methods: The study was a case- control study carried out on 45 adolescent boys with T1DM aged 12-18 years and 37 healthy control boys of similar age .The cases and controls were divided into four subgroups according to their pubertal stage (Tanner stage 2- 5).They were subjected to full history, reviewing their medical records, and clinical examinations (Auxology, Blood pressure and Pubertal assessment). Serum total adiponectin level, total testosterone, sex hormone- binding globulin level and free testosterone level were determined by ELISA technique in addition to glycated haemoglobin and fasting blood glucose. Results: Adiponectin serum level (±SD) was significantly higher in T1DM boys compared to healthy control group (12.93 ± 5.24µg/ml versus 8.91± 3.21µg/ml) (P<0.001).Such higher serum levels of adiponectin were detected mainly at Tanner stage 2 (16.57 ± 4.60µg/ml vs 11.88±3.39µg/ml) (P=0.025) and Tanner stage 3 (12.77±3.71µg/ml vs.6.59±1.54µg/ml) (P=0.002). Adiponectin levels decreased significantly during pubertal development in control group and T1DM group. The rate of decline in adiponectin serum level in T1DM boys was more smooth and regular in diabetic than control group. In T1DM boys adiponectin levels were negatively associated with pubertal stage, age, total testosterone, free testosterone, intermediate / long acting insulin dose and positively to HbA1c. No correlation was detected with SHBG or BMI. In control group adiponectin levels were negatively associated with pubertal stage, total testosterone and BMI. Conclusion: Adiponectin serum levels in adolescent boys with type 1 diabetes were significantly higher than control mainly at early puberty. It decreases significantly during pubertal development and correlated negatively to pubertal stage, total and free testosterone levels, intermediate / long acting insulin dosage and positively to HbA1c . |