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العنوان
Innovative Non- invasive diagnostic tool for
HCV infection in Egyptian patients/
المؤلف
Mohammed,Olla Abdalla Elshahat
هيئة الاعداد
باحث / علا عبدالله الشحات محمد
مشرف / أحمد شوقى الصوابى
مشرف / أحمد شوقى الصوابى
مشرف / أحمد محمد الصاوى
تاريخ النشر
2016
عدد الصفحات
105.p:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب الباطني
تاريخ الإجازة
1/1/2016
مكان الإجازة
جامعة عين شمس - كلية الطب - Internal Medicine
الفهرس
Only 14 pages are availabe for public view

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from 105

Abstract

hemical reactions can be induced at a distance due
to the propagation of electromagnetic signals during intermediate chemical stages. Although it is well known at optical frequencies, e.g. photosynthetic reactions, electromagnetic signals hold true for much lower frequencies as well. In E. coli bacteria such electromagnetic signals can be generated by electric transitions between energy levels describing electrons moving around DNA loops. The electromagnetic signals between different bacteria within a community are a “wireless” version of intercellular communication found in bacterial communities connected by “nanowires”. The wireless broadcasts can in principle be of both the AM and FM variety due to the magnetic flux periodicity in electron energy spectra in bacterial DNA orbital motions (Widom A. et al 2012 ).
The results of this study report that Electro- Magnetic Signal Detection (EMSD) can be utilized to diagnose a specific disease using a simple device. The efficacy of C-FAST device in recording and replaying the molecule signature of HCV, it is practical evidence that nucleotides in human body emit electromagnetic signals which are fully characterized and then these characteristics are used for its identification. When compared to the gold standard PCR technique, the C-FAST device has a remarkably high sensitivity and specificity.
The aim of this work is to assess if we can use C-Fast instead of PCR in detection of HCV infection in Egyptian patients.
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The current cross-sectional study was conducted on three hundred cases , PCR for HCV , HCV antibodies & C-FAST were done for all the patients .
This study revealed that C-FAST is highly sensitive for detection of HCV showing sensitivity 100% , specificity 69.2%, positive predictive value equals 98.6 % & negative predictive value equals 69.2 %.
This study clearly demonstrates that C-FAST is a noninvasive device, no blood sample, chemicals, kits or sophisticated laboratory equipments are needed and consequently no cost per case. Moreover, diagnosis of HCV using C-FAST is very rapid. These advantages are expected to have a huge impact on the diagnosis and screening programs of HCV worldwide where only few millions of 180 million HCV patients are already diagnosed. Taking into account the prospects of emerging new HCV therapies which are expected to be very potent, orally administered avoiding interferon therapy, the need for rapid and mass screening of HCV worldwide will be growing over the next few years (Dieterich D. et al. 2012) .
The availability of a simple, rapid, accurate, and non-invasive method for HCV diagnosis in the era of an oral effective regimen of HCV therapy could be a turning point in HCV history. Easy diagnosis and effective treatment will prolong life and prevent death from liver disease in millions of HCV patients. C-FAST is a non-invasive device capable of
identifying HCV infected patients instantly, making it ideal for
diagnosis of HCV and mass screening program (Widom A. et al 2012).