الفهرس 
INTRODUCTION & AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
This work was conducted to assess the usefulness of plasma MMP 1 and TIMP1 measurements as markers for metastasis in prostate cancer patients. Moreover this work also aimed to investigate the clinical utility of f/t PSA ratio as a
superior marker to tPSA in prostate cancer diagnosis.
Plasma TIMP1 was statistically significant increase in group of prostate cancer patients with local metastasis and group of prostate cancer patients with distant bone metastasis when each group compared to the group without metastasis.
On the other hand, plasma MMP 1 showed no statistically significant difference among all studied groups. This study was found that ALP was statistically significant increase in prostate cancer patients with distant bone metastasis versus the group without metastasis but there was no significant difference in group with local metastasis versus the group without metastasis.
When logistic regression analysis test and ANOVA test were applied, they were revealed that:
- f/t PSA ratio was the best discriminating marker in prostate cancer diagnosis (over t-PSA)
- Plasma TIMP 1 not MMP 1 was the best marker to
discriminate prostate cancer with local metastasis.
- ALP was the best marker to detect distant bone metastasis in prostate cancer patient.
- Plasma TIMP 1 concentration of3000 J.tg/L was shown to be
the best cut-off value to detect extracapsular invasion in
prostate cancer patients (88% sensitivity and 62%
specificity).