الفهرس 
Review of literatureOnly 14 pages are availabe for public view
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Abstract
Obsessive compulsive disorder (0.C.D) is an anxiety
disorder manifested by either obsessions and/or compulsions that
cause significant distress or dysfunction in social or personal
areas. The life prevalence of obsessive compulsive disorder in the
general population is estimated at 2to 3 percent. Some researchers
have estimated that the disorder is found in as many as 10 percent
of outpatient in psychiatric clinic. These figures make obsessive
compulsive disorder the fourth most common psychiatric
diagnosis after phobias; substance related disorder, and major
depressive disorder. Structural and functional neuroimaging studies implicate
basal ganglia structures especially the striatum, as well as
orbitofrontal hyperactivity in the pathophysiology of O.C.D. Data reported by C.T. and M.R.I. studies with significant
difference between ventricle to brain ratios (VBRs) of O.C.D.
patients and normal controls with reported significant reductions
in rCBF measurments of OCD patients compaired with healthy
controls in seven brain regions the right and left superior frontal
cortex, right inferior frontal cortex, left temporal cortex, left
parietal cortex, right caudate neucleus and right thalamus. A number of ERP studies revealed a decreased slow wave
(SW) (post P300 latency), a trend towards decreased P300 latency and a greater N200 amplitude in obsessive compulsive disorders.
The aim of this study is to detect any neurophysiological
and any functional cognitive impairment in OCD patients and to
find out there is any correlation between the occurrence of those
changes. The study included 20 OCD patients referred from the
outpatient clinic of psychiatry in El-Menoufiyia hospitals
diagnosed according ICD- 10. The severity of illness was graded
by the Y - BOCS and the predominance of symptoms by the YBOC
symptoms chicklist. Patients on medications or other
comorbid medical or neuro physiological disorders were
excluded. Twenty normal subjects were selected as a control
group. Both groups were matching for age (patient mean 28.15 +
8.49 years, range 15 -45, control mean 28.40 t5.58, range 19-39
years P>0.05) for sex (each group included 15 males 70% and 5 females 30%) and for education (patient mean 13.90 2 2.9 1, range
6-1 6 years, control mean 13-95? 2.87, range 6- 16 years, P> 0.05).
Obsessive and mixed groups of OCD represent the majority of
cases where pure compulsive cases are rare as reported in our
I
study and supported by others.
There is no sex difference as regards severity of illness, This
implies that sex does not determine the illness course or outcome.