الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Recurrent breast cancer is a breast cancer that recurs after initial treatment with either modified radical mastectomy (MRM) or breast conservation therapy (BCT)
There are three main types of recurrent breast cancer: local, regional and metastatic. Local recurrent breast cancer may be after breast conservative surgery (BCS) in the preserved breast tissue or after modified radical mastectomy (MRM) in the skin along the scar of the previous operation .Regional recurrent breast cancer is in the regional lymph nodes. This study was concerned with the locoregional recurrence.
The incidence of locoregional recurrence (LRR) after MRM and BCS is approximately 10 % to 15 %
The aim of the present study was to assess and identify the predictors and prognostic factors for locoregional recurrent breast cancer and the management policy for those patients.
This study was conducted retrospectively and prospectively on 30 female patients suffering from locoregional recurrence and were subjected to full history taking, physical examination and the proper laboratory, radiological and pathological investigations.
The contributing factors that were analyzed in this study include the age at time of diagnosis of the primary tumor , site of primary tumor, lymph node status after primary surgery, size of primary tumor, lymphovascular invasion of the primary tumor, safety margin status specially after BCS, histopathological subtype and grading of the primary tumor, presence of extensive intraductal component (EIC) at the primary tumor, the ER, PR, Her2 and Ki 67 status of the primary tumor, adjuvant and neoadjuvant chemotherapy , radiotherapy and hormonal therapy at time of managing the primary tumor and the disease-free interval(DFI).
The study found that the factors increasing the incidence of LRR include: young age, heavy affection of the axillary lymph nodes with extra nodal invasion, positive margin, high histological grade, presence of lymphovascular invasion, presence of extensive intraductal component, ER negative tumors, absence of radiation therapy at the time of the initial BCT and incompliance of adjuvant hormonal therapy and chemotherapy.
Treatment of locoregional recurrent breast cancer include : Salvage mastectomy if the LRR was after BCT and wide local excision whenever possible for chest wall recurrence after MRM.