الفهرس 
review of literatureOnly 14 pages are availabe for public view
 |  | from | 160 |  |  |
| | | from | 160 | | |
Abstract
Hepatitis C virus infection is widespread which it affects millions of people worldwide. Egypt has the highest worldwide prevalence of persons carrying anti-HCV antibodies. HCV-infected person serve as a reservoir for transmission to others and they are at risk for developing chronic liver disease including fibrosis, cirrhosis, and hepatocellular (HCC).
Aim of the work: this study was conducted to investigate the liver function parameters (ALT, AST, Bilirubin, Albumin) and lipid profiles in blood donors with and without hepatitis C and determine if there is the relation between serum lipid profile (total cholesterol, triglycerides, HDL, LDL) and spontaneous clearance of HCV in blood donors. The role of the aminotransferase lipid profile ratio in the spontaneous clearance of hepatitis C virus will be investigated.
Result: the 50 patient who were serologically positive for HCV antibodies were subjected to quantitative real – time PCR for HCV-RNA. Of these, 25 were below the detection limit; this group represented group II, which was positive for HCV antibodies and negative for HCV-RNA. The remaining 25 patients represented group III, which was positive for HCV-RNA with various degrees of HCV-RNA viral-load levels. The positive HCV-RNA group showed a significance increase in the aminotransferase-lipid profile compared to other study groups (p<0.05) except for ALT-LDL cholesterol.
Conclusions: lipids may an important role in clinical outcome of hepatitis C virus infection. AST-HDL may be playing an important role in HCV spontaneous clearance without HCV treatment.
Recommendation: further large-scale independent studies are needed to validate this index.