الفهرس 
Synthesis of Phthlazine derivativesOnly 14 pages are availabe for public view
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Abstract
his thesis describes synthesis of new phthalazine derivatives through the
reaction of nucleophiles with chlorophthalazine as a key intermediate
with the aim to obtain new derivatives with remarkable antimicrobial activities.
Therefore, this thesis contains the following parts:
The Introduction chapter summarize the previous research work on the
synthesis, reactions and biological evaluation of the phtalazine derivatives based
on the literature review from different research groups worldwide. While the
results and discussion chapter highlighted the synthesis and characterization of
the target compounds including the discussion of the experimental methods
adopted for the synthesis of the designed compounds as well as the different
analytical methods applied for the characterization of the new phthalazine
analogues. In this part the author synthesized 2-(4-methoxybenzoyl) benzoic
acid 3 by the reaction of anisole with phthalic anhydride under Fridel Craft’s
condition. Condensation of benzoic acid derivative with hydrazine hydrate in
boiling ethanol afforded the target compound 4-(4-methoxyphenyl)-2Hphthalazin-
1-one 4. Further chlorination of compound 4 with POCl3 afforded 1-
chlorophthalazine 5 as a key intermediate in good yield. The key intermediate 1-
chloro-4-(4-methoxyphenyl) phthalazine 5 was used for the diversification of
phthalazine core at the C-4 position. Thus, the phthalazine derivatives with C4-
amine side chains and different carbon spacers between the two nitrogen were
synthesized after reaction of the key intermediates,Compound 5 with excess of
appropriate amines, through a nucleophilic aromatic substitution reaction with
release of chloride at C-4 of the aromatic nucleus of phthalazine.