الفهرس 
Synthesis of Pyridine-2,6-dicarboxylic AcidOnly 14 pages are availabe for public view
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Abstract
1. The thesis startes with an introduction covering a general review for the chemistry of
2,6-pyridinedicarboxylic acid (dipicolinic acid) till 1997. It includes also a special part
presenting the obtained results followed by the experimental part and ended with a list of 280
references.
2. The thesis includes a course of investigation to synthesize a series of some peptide
derivatives. Coupling of 2,6-pyridine dipicolinoyl dichloride (23) with amino acid methyl esters to
afford 2,6-bis (aminocarbonyl)pyridine methyl ester derivatives (125) was preformed followed by
treating with hydrazine hydrate to give the corresponding dihydrazide derivatives (126).
. o (’nNI o
NH
O
0 _R
a a
b_H _CO_O_M_e
., R’t’NH ’NH!R
Ao o o
NAy TEA
(23)
o
I I
CH3 CH3
(125)
(126)
3. Some dihydrazone derivatives (127) have been prepared from the reaction of the diydrazide
derivatives (126) with benzaldehyde or p-chlorobenzaldehyde.
(127)
4- Hydrolysis of diesters (125) with sodium hydroxide gave the corresponding diacid derivatives
(128).
0
(128)
5- Dihydrazide derivatives (88) and (126) reacted with some acid · anhydrides to give
the corresponding diamide-(129) and tetraamidediimide derivatives (130), respectively.
(129) (130)
6. Condensation of dihydrazides (88) and (126) with some tetra carboxylic acid dianhydrides,
namely I ,2,4,5-benzenetetra carboxylic acid dianhydride or I ,4,5,8-naphthalenetetracarboxylic
acid dianhydride was undertaken to afford different macrocyclic polyamide derivatives (131) and
(132), respectively.
0y-”N-”y0
0y-”N-”y0
:a:a :
oNu_;o(
oNu_;o(
(131a) (131b)