الفهرس 
AUTISMOnly 14 pages are availabe for public view
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Abstract
Autism is a complex, behaviorally defined neuron-developmental disorder characterized by significant impairments in social interaction, verbal and non-verbal communication, and by restrictive, repetitive and stereotypic patterns of behavior.
Autism spectrum disorders-include:
1. Autistic disorder.
2. Asperger’s syndrome.
3. Pervasive developmental disorder-not otherwise specified (PDD-NOS) PDD-NOS; also called (typical autism) is diagnosed when the criteria are not met for a more specific disorder.
4. Rett’s syndrome.
5. Childhood disintegrative disorder.
Autism is not a disease with a single etiology, but it is a heterogeneous behavioral syndrome associated with many etiologies.
In 10-30% of cases, there is an identifiable etiology (secondary autism). In the majority of cases, there is no obvious cause (primary autism).
Neurological, genetic, environmental factors could contribute to autism development.
Studies suggest that substantial gains can be achieved by interventions initiated prior to 24 months. Treatment means include Psycho-educational treatment (Mind-Body Therapy) and psychopharmacology.
Generally, autism follows a steady course without remission, no cure is known. Children recover occasionally, so that they lose their diagnosis of ASD.
Toxic levels of heavy metals and low levels of essential minerals have been suggested to play a critical role in the pathogenesis of autism spectrum disorders (ASD).
This study documents the levels of zinc and copper in hair samples of Egyptian children with ASD and correlates these levels with severity of the disease.
It was conducted in Psychiatry Clinic in Children’s Hospital, Faculty of medicine, Ain Shams University. It included 30 patients with AD and 30 healthy children served as a control group. All patients were subjected to full history, clinical examination, psychiatric evaluation (DSM-V criteria, IQ assessment and CARS) and hair zinc and copper was done.
The present study revealed that there was no significant difference between patients and controls regarding hair zinc and copper.
There was a significant positive correlation between age and hair zinc level among cases, however no significant correlation was found between age of disease onset and hair zinc level.
There was a significant negative correlation between age and hair copper level among cases, however no significant correlation was found between age of disease onset and hair copper level.
IQ was lower in patients than controls. There was highly significant correlation between CARS and IQ.
Defining features of autism as no verbal communication, absent eye to eye contact, stereotyping and socially aloof behavior are clear among our patients in this study.
Autism is more common in males than females as it is more than twice as common in boys as in girls.
Conclusion:
from this study we conclude that the hair copper and zinc were within normal range among the patients with ASDs. There was no significant difference between patients and controls as regarding hair levels of zinc and copper.
Autism is a complex, behaviorally defined neuron-developmental disorder characterized by significant impairments in social interaction, verbal and non-verbal communication, and by restrictive, repetitive and stereotypic patterns of behavior.
Autism spectrum disorders-include:
1. Autistic disorder.
2. Asperger’s syndrome.
3. Pervasive developmental disorder-not otherwise specified (PDD-NOS) PDD-NOS; also called (typical autism) is diagnosed when the criteria are not met for a more specific disorder.
4. Rett’s syndrome.
5. Childhood disintegrative disorder.
Autism is not a disease with a single etiology, but it is a heterogeneous behavioral syndrome associated with many etiologies.
In 10-30% of cases, there is an identifiable etiology (secondary autism). In the majority of cases, there is no obvious cause (primary autism).
Neurological, genetic, environmental factors could contribute to autism development.
Studies suggest that substantial gains can be achieved by interventions initiated prior to 24 months. Treatment means include Psycho-educational treatment (Mind-Body Therapy) and psychopharmacology.
Generally, autism follows a steady course without remission, no cure is known. Children recover occasionally, so that they lose their diagnosis of ASD.
Toxic levels of heavy metals and low levels of essential minerals have been suggested to play a critical role in the pathogenesis of autism spectrum disorders (ASD).
This study documents the levels of zinc and copper in hair samples of Egyptian children with ASD and correlates these levels with severity of the disease.
It was conducted in Psychiatry Clinic in Children’s Hospital, Faculty of medicine, Ain Shams University. It included 30 patients with AD and 30 healthy children served as a control group. All patients were subjected to full history, clinical examination, psychiatric evaluation (DSM-V criteria, IQ assessment and CARS) and hair zinc and copper was done.
The present study revealed that there was no significant difference between patients and controls regarding hair zinc and copper.
There was a significant positive correlation between age and hair zinc level among cases, however no significant correlation was found between age of disease onset and hair zinc level.
There was a significant negative correlation between age and hair copper level among cases, however no significant correlation was found between age of disease onset and hair copper level.
IQ was lower in patients than controls. There was highly significant correlation between CARS and IQ.
Defining features of autism as no verbal communication, absent eye to eye contact, stereotyping and socially aloof behavior are clear among our patients in this study.
Autism is more common in males than females as it is more than twice as common in boys as in girls.
Conclusion:
from this study we conclude that the hair copper and zinc were within normal range among the patients with ASDs. There was no significant difference between patients and controls as regarding hair levels of zinc and copper.