الفهرس 
AbstractOnly 14 pages are availabe for public view
 |  | from | 213 |  |  |
| | | from | 213 | | |
Abstract
The thesis aims to design, synthesis and biological activity testing of new tetrazole derivatives in conjugation with aroylhydrazones, thiazolidinones and oxadiazoles. Synthesized compounds were tested for their antimicrobial and anticancer activity. In addition, the effect of incorporation of 1-phenyl-tetrazole moiety into propyl paraben on its antifungal activity was also studied. A molecular modeling approach was performed to study physicochemical properties of the synthesized compounds.
The thesis is divided into 7 parts:
Introduction This part provides a general introduction about the pharmacological properties of tetrazole moiety, aroylhydrazones, thiazolidinones and oxadiazoles.
Research Objectives discuss the design rationale for the synthesized compounds and the building up strategy of the new scaffolds.
Theoretical Discussion discuss the chemistry of synthesis to obtain the target compounds according to the adopted schemes and structure elucidation of the new compounds using infra-red, nuclear magnetic resonance and mass analysis.
Experimental work describes the experimental work of synthesis of the target compounds and their analysis data which includes melting point, infra-red, nuclear magnetic resonance, elemental analysis and mass analysis.
Biological activity describes the methods of testing the antimicrobial and anticancer activity of the synthesized compounds and discuss their results.
Molecular modeling the physicochemical properties of the synthesized compounds were calculated. Prediction of targets and metabolism was carried out.