الفهرس | Only 14 pages are availabe for public view |
Abstract In the Western world Acne vulgaris affects up to 85% of adolescent population, the prevalence of facial acne vulgaris among teenagers was 67.5%. The condition was more common among males (71.1%) compared to females (64.6%). Previous studies enquiring into the potential link between diet and acne vulgaris have shown controversial results. The relationship between diet and acne is unclear. However, a high glycemic load diet is associated with worsening acne. There is also a positive association between the consumption of milk and severity of acne. Other associations such as chocolate and salt are not supported by the evidence. There may be a relationship between acne and insulin metabolism and one trial found a relationship between acne and obesity. High-glycemic-load diets have recently been implicated in acne etiology because of their ability to increase the insulin demand and other factors associated with insulin resistance (eg, elevated fatty acids and obesity). Clinical and experimental evidence suggests that insulin may increase androgen production and affect, through its influence on steroidogenic enzymes, gonadotrophin releasing hormone secretion and sex hormone– binding globulin production. Additionally, insulin has been shown to decrease a binding protein for IGF-I, which may facilitate the effect of IGF-I on cell proliferation. Overall, these events may influence 1 or more of the 4 underlying causes of acne: 1) increased proliferation of basal keratinocytes in the pilosebaceous duct, 2) abnormal desquamation of follicular corneocytes, 3) androgen-mediated increases in sebum production, and 4) colonization and inflammation of the comedo by Propionibacterium acnes. This study aimed to study the relationship between dietary intake and levels of insulin like growth factor -1 with Acne vulgaris among adolescents and adults. Our subjects divided into two studied groups: Cases group: include adolescents and adults aged 11-28 years of both sex suffering from acne. Control group: include adolescents and adults matched with the cases in age and sex but free from acne |