الفهرس | Only 14 pages are availabe for public view |
Abstract Circulating collagen III protein was identified in serum samples of CHC patients by using western blot technique at 70 kDa. Using mono-specific collagen III antibody as a probe in ELISA, in contrast to negative control individuals, elevated serum collagen III levels were detected in CHC patients. These levels were significantly differ (P <0.0001) between CHC patients and controls. Thus, detection of collagen III as individual or in combination with other serum markers in liver diseases might be helpful in differential diagnosis between chronic hepatitis C patients with different fibrotic liver stages and those without. |