الفهرس 
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Abstract
Myocardial injury is a frequent consequence of carbon monoxide (CO) poisoning. Oxidative stress affection seems to be a relevant mechanism in the patho-physiology of patients with acute CO poisoning.
Methodology:
This study included Sixty two CO intoxicated patients who were admitted to Poison Control Center, Ain Shams university Hospitals, between Jan 2007-june 2008.We have investigated some plasma oxidative stress parameters of individual exposed to CO, including Total Antioxidant Capacity (TAC), malondialdehyde (MDA) and nitric oxide (NO).Cardiac muscles damage assessed by determining the serum levels of some cardiac markers as aspartate amino transferase(AST), Total creatine phosphoknase(CPK), creatine kinase-MB(CPK-MB), Lactate dehydrogenase(LDH), troponin I and N-terminal prohormone of brain natriuretic peptide (NT-ProBNP).In addition to carboxyhemoglobin (COHb) levels and Blood pH were also determined to give an indication on the severity of CO exposure. All the investigated parameters were also conducted to 15 healthy individuals who were considered as control group.
Results:
As expected, compared to control group, the patients groups mild and severe showed a significant increase in plasma level of COHb level,oxidative stress parameters, MDA and NO were also increased along with the cardiac markers troponin I, NT-Pro BNP peptide. On the other hand ,there was a sharp reduction in blood pH and Total antioxidant capacity(TAC), NT-Pro BNP showed a significant positive correlation with COHb level and a negative correlation with TAC, while TAC showed a significant negative correlation with COHb level. Conclusions and recommendations:
Myocardial injury is frequently accompanied with patients of CO poisoning. The oxidative stress indices are significantly affected after CO poisoning .In general it’s suggested natural products with antioxidative activity may help to relieve the clinical symptoms of patients who get exposed to CO. The recommendation is to include antioxidant as a supplemented therapeutic strategy along with hyperbaric oxygen treatment which is expected to relieve the clinical symptoms of CO intoxicated patients.