الفهرس 
Literature ReviewOnly 14 pages are availabe for public view
 |  | from | 16 |  |  |
| | | from | 16 | | |
Abstract
The present work aimed to study the possibility of synthesizing, characterizing of CMCS as modified water soluble chitosan derivative and electrospun it to obtain CMCS nanofibers web and use computer software to charterize it. This work divided into three main parts:
Part I:: Preparation, characterization of Carboxymethylchitosan /
Modification of Chitosan(CS) using monochloroacetic acid in the presence of sodium hydroxide under different reaction conditions were studied to determine the optimum conditions for preparing the O-carboxymethylchitosan (O-CMCS). The prepared O-CMCS was characterized by its nitrogen content, degree of substitution and its solubility in different solvent or water under different pH values.
Part II: Electrospinning of Carboxymethylchitosan:
Chitosan is a well known anti-microbial polymer. It is desired to develop and evaluate inexpensive chitosan based structures with high surface area using electrospun nanofibers. Due to the difficulty in electrospinning chitosan, Carboxymethylchitosan was synthesized and electrospinning trials of its solutions were conducted. Carboxymethylchitosan nanofibers were obtained from Carboxymethylchitosan solutions in the presence of PVA as fiber aiding polymer-using water as a solvent. Nanofiberwebs of fiber diameter range of 51-459 nm was obtained from 6%-20% Carboxymethylchitosan solution in water was successfully electrospun in an electric field of 3 and 5 kV/cm. A cotton gauze fabric was the substrate for the carboxymethychitosan mats. Contact kill performance of the structures against a range of microbes was carried out using the disc diffusion method. The trials indicated that the nanofiberwebs exhibited an excellent antimicrobial behavior. In other words, for equal area (covered discs used), the antibacterial properties are more or less at the same level for both films and nanofibers used, however, the weight amount used of the material is higher by a factor of 103 than the material used in case of nanofibers for the same material. Moreover, finishing of textiles by making use of nanofibers are much easier than by formation of films on textile surfaces which might need a lot of precautions.