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Abstract Prostatic specific antigen (PSA) is a valuable tumor marker used for diagnosis and management of prostate cancer. Recently, PSA has been found in various female tissues and body fluids. Female breasts both normal and abnormal, including cancerous tissues, can produce PSA, and this production is regulated by androgens and progestins. This study was applied on 65 women suffering from breast cancer, 31 of 65 have benign breast hyperplasia and 34 have malignant breast cancer. Each group was divided into 2 groups, pre and postmenopause, both groups were compared with 15 normal cases. No significant difference in serum Total PSA concentration between any of the studied cases. However there were different variations in the distribution of PSA in the breast tumor tissue, with complete absence of any presence of the PSA in the tissue samples of the malignant after menopause patients. Conclusion: PSA distributed in pre and postmenopausal female with benign and malignant breast tissue, with absence of PSA in postmenopausal female with malignant breast cancer |