الفهرس 
FIVE-MEMBERED RING SYSTEMS:1,2,3-TRIAZOLEOnly 14 pages are availabe for public view
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Abstract
3-(5-Methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-pyrazole-4-
carbaldehyde (1) was synthesized via the reaction of excess Vilsmeier reagent with phenyl
hydrazone. The reaction of compound (1) toward active methylene derivatives led to give
compounds. The substituted pyrazole derivatives were prepared via reactions of compound 1
with hydrazine hydrate and different amino pyrazoles. On the other hand, compound 1 reacted
with P-methoxy acetophenone to give the α-β unsaturated chalcone derivative which in turn
react with each of ethyl cyanoacetate and malononitrile to give the corresponding derivatives,
Several new pyrrole derivatves were synthesized via the reaction of 2,5-dihydro-4,5-bis(4-
methoxyphenyl)-2-Thioxo-1H-pyrrole-3-carbonitrile with ethyl chloroacetate, chloroacetone, ω-
bromoacetophenone, ω-bromo-4-methylacetophenone, chloroacetonitrile or iodomethane to give
the corresponding s-alkylated derivatives. In addition, the antimicrobial activity of some selected
derivatives was studied.
2-amino-3-cyanopyridine derivatives were synthesized by treating cyclic compounds containing
active methylene group with arylidenemalononitrile in the presence of ammonium acetate. The
behavior of 2-amino-3-cyanopyridine derivatives toward some electrophiles as
triethylorthoformate followed by nitrogenious nucleophiles as hydrazine was reported; also, its
reactivity toward phenyl isocyanates, thiourea, formic acid and formamide was investigated,
with the aim of obtaining some interesting non-mixed heterocyclic compounds. In addition the
antimicrobial activity of some selected derivatives was reported.
2-Amino-1-aryl-1,4,5,6,7,8-hexahydro-4-phenylquinoline-3-carbonitrile derivatives were
synthesized by the reaction of cyclohexanone with 2-benzylidinemalononitrile and the
appropriate of aniline derivatives. The reactivity of some of these newly synthesized derivatives
toward carbon disulfide and further toward hydrazonoyl halides were also studied. In addition,
the antimicrobial activity of the newly synthesized derivatives was reported.
Keywords: Active methylene compounds, Nitrogenous compounds, pyridine derivatives, pyrrole
derivatives, pypridine derivatives, barbiturates, thiobarbiturates, biological activity, antimicrobial
compounds and anti-cancer compounds.