الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Most recently, Retinol binding protein 4 and Resistin have been introduced as a novel adipokines that play roles in regulating glucose metabolism and insulin sensitivity. High RBP4 and Resistin levels are associated with insulin resistance states suggesting that RBP4 and Resistin play key roles in the pathogenesis of insulin resistance in humans and reflects the magnitude of insulin resistance in subjects with obesity, Type 2 Diabetes Mellitus and non-obese subjects with family history of T2DM. The aim of this study is to study the modulatory effect of Vitamin A on blood glucose level of type 2 diabetic patients and its effect on serum concentrations of RBP4 and resistin. This study involved 40 individuals, 20 subjects with T2DM, and had taken Vitamin (A) for three months (dose 5 mg Vitamin A daily), 10 subjects with T2DM and 10 non diabetic subjects served as controls. Full history and clinical examination were taken to every subject. Laboratory vestigations were also carried out to all individuals including: Fasting blood sugar, hemoglobin, Lipid profile (total cholesterol, triglycerides, high density lipoprotein cholesterol, and low density lipoprotein cholesterol), Resistin and RBP4. Determination of insulin resistance by HOMA-IR was also carried out. Diabetes elevated fasting blood glucose level and serum levels of RBP4 and resistin compared to healthy control persons. Treatment of diabetic patient with vitamin A reduced fasting blood glucose level compared to diabetic non treated patients and serum levels of total cholesterol, LDL cholesterol compared to diabetic non treated patient and healthy control persons and resistin compared to diabetic patients before treatment with vitamin A while it increased serum level of HDL cholesterol compared to diabetic non treated patients. This study indicated that vitamin A induced a reduction in blood glucose level of type 2 diabetic patients through reducing serum levels of resistin, LDL cholesterol and increasing HDL cholesterol suggesting that vitamin A could be a promising anti diabetic agent.