الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
This study aimed to investigate the effect of dietary supplementation with ginger to evaluate its therapeutic effect against lung and kidney cancer and in combination with cisplatin as chemotherapy and radiotherapy in male Wistar albino rats (Rattus norvegicus).
Studies involve investigating the therapeutic role of ginger for better restoration of certain haematological parameters: (white blood cells count, red blood cells count, haemoglobin content, hematocrite value and platelets count ) Besides biochemical parameters (serum tumor necrosis factor alpha (TNF-α) level, advanced oxidative protein product (AOPP), urea, creatinine and uric acid ). Tissue parameters in both kidney and lung tissues: were estimated by determining the activitiy of antioxidant enzyme superoxide dismutase (SOD); as well as by determining the levels of reduced glutathione (GSH), Malondialdehyde (MDA) and Nitric oxide (NO) and histopathological changes of kidney and lung tissues.
Cancer induced a significant decrease in WBCs, RBCs, Hb, Hct value and platelets count with a significant increase in the serum tumor necrosis factor alpha (TNF-α) level, advanced oxidative protein product (AOPP), urea, creatinine and uric acid. Besides, it produced high levels of lung and kidney Malondialdehyde (MDA) and Nitric oxide (NO) with significant decrease in reduced glutathione (GSH) and superoxide dismutase (SOD). Ginger + cisplatin + radiation manifested good amelioration against NDMA + CCl4 group in the studied haematological and biochemical parameters.
In histological investigation showed that rat groups treated with ginger alone showed no deviation from control group. While rats injected with NDMA + CCl4 showed sever degenerative changes. On the other hand, groups injected with NDMA + CCl4 and treated with ginger + cisplatin + radiation group showed an even more remarkable effect showing histopathological lung and kidney profiles close to those of the control group when compared with NDMA + CCl4 group.
In conclusion, the results obtained in the current study demonstrates that the oral administration of ginger in combination with cisplatin and radiation show a remarkable effect in enhancing lung and kidney functions and may thus be of therapeutic potential in treatment of lung and kidney cancer.