الفهرس 
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Abstract
The present investigation was carried out on 31 clinically normal adult donkeys (Equus Asinus) of both sexes. The mean age was 5.9 ± 0.38 years and the mean weight was 135.45 ± 2.2 kg. All animals were subjected to surgical induction of core lesion at mid SDFT. Intralesional injection of placebo in 7 animals (group I, control group); freshly prepared PRP in 12 donkeys (Group II) and DMSO 10% in 12 donkeys (Group III) were performed at 5th, 15th and 30th days post induction of the core lesion for treatment. The relationship between the ultrasonographic and crossponding histopathological examination was evaluated. Clinical, ultrasonographic, gross pathological and histopathological evaluation of the core lesion was conducted before and during 5th; 15th; 30th; 45th; 60th and 90th days post induction of the core lesion.
Clinical assessment of the DMSO treated group revealed, significant (p ≤ 0.05) improvement of all clinical parameter during the study. Complete disappearance of clinical signs was observed during 60th and 90th day for local heat and during 90th day for local pain and lameness.
Clinical assessment of the PRP treated group revealed, significant (p ≤ 0.05) improvement of all clinical parameter during study. Complete disappearance of clinical signs was observed during 60th and 90th day for local heat and during 90th day for local pain and lameness.
In the present study, comparison between PRP and DMSO treated group proved that, although the recorded values were lower in PRP treated group than DMSO treated group, there was no significant difference between both groups in respect to local heat, pain, lameness and swelling except that, the mid metacarpal circumference in the PRP treated group were significant (p ≤ 0.05) lower than that of DMSO treated group at 45th, 60th and 90 days post induction.
Ultrasonographic examination of DMSO treated group showed significant (p ≤ 0.05) decrease of SDFT CSA, SDFT width, core lesion CSA, core lesion width, core lesion length, FES and FAS during the study. At the end of the study and the core lesion CSA represented 28.13 % of the tendon CSA.
Ultrasonographic examination of PRP treated group showed significant (p ≤ 0.05) improvement in the mean SDFT CSA, SDFT width, core lesion CSA, core lesion width and core lesion length, FES and FAS during the study. At the end of the study and the core lesion CSA represented 7.53 % of the tendon CSA.
Quantitative ultrasonographic finding of the DMSO treated group showed gradual infiltration with multiple hypoechogenic and less echogenic dotes till the end of the study. Histopathological examination showed variable degrees of hemorrhage, inflammatory cells and fibroblast infiltration. At the end of the study, the predominant collagen was thin semi parallel aligned.