الفهرس 
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Abstract
Naturally occurnng coumarins such as psoralen, xanthotoxin and bergapten have been used many years in medicine in the treatment of vitiligo, psoriasis and other deimal diseases. Currently the only commercial source is plant materials.
Ammi majus L. is considered as one of the most important sources of coumarins, it is also regarded as one of the most important medicinal plants grown in Egypt.
The aim of the present investigation was:
A-Quantitative determination of coumarins of Ammi majus L. crude fruits and fruit residue, e.g., bergapten, imperatorin, isopimpinellin, marmesin, xanthotoxin, and xanthotoxol.
B- Production of the most important conmanns (bergapten marmesin and xanthotoxin) by funt,ri from extraction residues of Ammi majus L. fruits as follows:
!-Cultivation of local and introduced fungi onAmmi majus L. fruit residue.
2-Selection of the most potent orgamsms that favors bergapten marmesin, xanthotoxin production.
3-Physiological studies to determine the optimum conditions suitable for the biologically active coumarins production.
4-Semi-pilot studies for the economic comnarins production.