الفهرس 
Congenital Heart DiseasesOnly 14 pages are availabe for public view
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Abstract
Children with cardiac disease often have disruptions in the balance of hemostasis, which paradxicall could result in bleeding thrombosis, or both cyanotic CHD is more commonly reported to have known hemostatic disorders with an increased risk of stroke and thromboembolism. as compared with acyanotic CHD, however, patients with acyanotic CHD (ACHD) may also have a mild bleeding disorder. In patients with CCHD persistent mixing of poorly oxygenated venous with arterial blood due to a Rt-to-Lt shunt results in chronic hypoxia which leads to secondary erythrocytosis resulting in blood hyperviscosity and high-shear stress of the vessel wall and platelet surface cause chronic vascular endothelial cell activation and dysfunction as well as platelet activation, both favouring thrombogenesis in the microcirculation with increased risk of thromboemolism and stroke. Acyanotic CHD exhibited a higher degree of platelet activation when compared with the healthy controls. Hemodynamic disturbances with accelerated and turbulent flow may be responsible for the increase platelet and vascular endothelial cell activation in ACHD and increase the risk for thromboembolic complication.