الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Vascular endothelial growth factor (VEGF) represents a crucial factor in terms of angiogenesis during the formation of placenta. (VEGF) is over expressed breast cancer. Thus, this study focuses on polymorphism of 1154 G/A, 634 G/C, 405 C/G, 936 C/T, 1612 G/A and it aims at recognizing the genetic variation in vascular endothelial growth factor (VEGF) gene. This helps discovering the early stage of pathogenesis of the breast cancer. The early discovery leads to important advances in prevention of the breast cancer. It also helps knowing the prognostic characteristics of the tumors in the Egyptian cases. We Concluded : There is a great probability of association of VEGF polymorphism with the occurrence of breast cancer among Egyptian cases. Regarding the VEGF polymorphism, the cases in this study showed that there were a significant higher frequency of 1154 A allele, 634 C allele, 405 G allele 936 T allele and 1612 A allele carriage rates that might signify a higher production to the VEGF protein In Egyptian population. a) PCR is a relatively simple and accurate method for detection of VEGF polymorphism in breast cancer cases. Therefore we recommend : Recognition and characterization of VEGF polymorphism by polymerase chain reaction (PCR) can help in diagnosis of susceptible cases for early discovery and prevention of breast cancer diseases among affected families. Routine screening for breast cancer mutations for all Egyptian women in order to setup an appropriate method of prophylaxis against breast cancer disorder. We also recommended for proper environmental behavior, combating pollution and stopping the bad health habits like smoking to protect individuals carrying the unfavorable genes making them susceptible to breast cancer.