الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Cataract is a clouding of the eye lens which cause visual impairment and of multifactorial origin and unknown cause. Cataractous lenses were observed in more than 17 million people and 2800 daily new cases are detected throughout the world. Two different forms of cataractous lenses are known; congenital and senile type. Congenital cataract occurred through environmental and genetic factors and observed during intra-uterine growth Senile cataracts developed as a result of age related changes in opacification of lens fibres. The study was approved by Mansoura Medical Research Ethics committee, Egypt. Written informed consent had been taken before surgery from the adults or parents of children. Fifteen congenital and 56 senile cataractous lenses were obtained from patients admitted to Ophthalmic Center, Mansoura University, Mansoura, Egypt. In case of senile cataract surgery was performed by extracapsular cataract extraction technique. However, senile patients were categorized according to their age-related diseases such as (diabetic, hypertensive and diabetic, hypertensive and renal failure, hypertensive and cardiovascular, cardiovascular disease, hepatic and diabetic, hypertensive, diabetic and cardiovascular) (n=7). Congenital infant ranged from 1-4 years meanwhile senile from 60-80 years old. In case of congenital cataract surgery was performed by irrigation/aspiration technique. Lenses of children were selected for congenital (n=20) while the adult were used for comparing senile cataract. Normal non-opaque lenses were collected from children (n=5) 1-4 years and adult (n=6) of 20-30 years within 1–4 hours of death.
Conclusion: Finally, it can be concluded that there are different pathways for developing congenital and senile cataractous lenses. Aging related diseases represent the main factors which induce metabolic alterations of the lens and increase the oxidative stress and liberation of free radicals involved in the formation of glycation end products which increase cataract formation. Also, it can be concluded that the alterations of the assayed isoenzyme fractions led to alteration of lens function and contributed to cataract formation.