الفهرس 
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Abstract
Male albino rats were divided into 6 groups; untreated (control), animals treated with montelukast (10mg/kg/day) (MLD), montelukast (20 mg/kg/day) (MHD), DOX-treated (DOX, 15mg/kg), concomitant DOX with MLD-treated (DOX+MLD) and concomitant DOX with MHD-treated (DOX+MHD) groups. Administration of montelukast was started 11 days before DOX administration and continued for 3 days. Administration of a single dose of DOX (15 mg/kg, i.p) caused significant deterioration in renal function. Co-administration of MLD but not MHD with DOX resulted in a decrease in serum creatinine. Male albino rats were divided into 6 groups; untreated (control), animals treated with DIA (25mg/kg/day) (DLD), DIA (50 mg/kg/day) (DHD), DOX-treated (DOX, 15mg/kg), concomitant DOX with DLD-treated (DOX/DLD) and concomitant DOX with DHD-treated (DOX/DHD) groups. Administration of DIA was started 11 days before DOX administration and continued for 4 days. Administration of a single dose of DOX (15 mg/kg, i.p) caused significant deterioration in renal function. Co-administration of either low or high doses of DIA with DOX resulted in decreasing this toxic effect. Male albino rats were divided into 6 groups; untreated (control), animals treated with ketotifen (1mg/kg/day) (KLD), ketotifen (10 mg/kg/day) (KHD), MTX-treated (MTX, 20mg/kg), concomitant MTX with KLD-treated (MTX/KLD) and concomitant MTX with KHD-treated (MTX/KHD) groups. Administration of ketotifen was started 11 days before MTX administration and continued for 3 days. Administration of a single dose of MTX (20 mg/kg, i.p) caused significant deterioration in renal function, designated by the increase in both serum creatinine and urea concentrations. Co-administration of either low or high doses of ketotifen with MTX resulted in decreasing toxic effect. In conclusion, MLD, DLD and DHD had protective effects on DOX induced nephrotoxicity. In addition, KLD and KHD had protective effects against MTX induced nephrotoxicity.