الفهرس 
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Abstract
T1D is an autoimmune disease, in which Beta cells of the pancreas are destructed resulting in a harmful state of hyperglycemia. One of the important factors that recent studies suggested that vitamin D deficiency has a role in the development of this disease.
Vitamin D insufficiency is a risk factor for autoimmune diseases and other disorders. Although optimal supplement dosing with regard to immune and Beta cells function is not known.
The aim of this study was to evaluate serum 25-hydroxyvit D status in children with T1D and to correlate it with different clinical and laboratory parameters.
Our study included two groups; Group I: included 53 patients with T1D and furtherly subdivided into 2 subgroups; group Ia included 43 patients with poor glycemic control and group Ib included 10 patients with good glycemic control. Another 15 apparently healthy children and adolescent’s age and sex matched to diseased group were taken as a control group and classified as group II.
The studied groups were subjected to thorough history taking, clinical examination and laboratory investigations including: fasting blood glucose, glycosylated hemoglobin (HbA1c %), serum calcium level and 25-hydroxyvitD level.
As regard the results of the current study, we found that 25-hydroxyvitD level was lower in T1D children than the control. This finding may support the idea that vitamin D deficiency may be an important factor behind the development of T1D, perhaps with an immunological background.
Also, serum 25-hydroxyvitD levels was lower in group Ia than group Ib. Also, there were significant lower serum calcium levels in group I than group II .Moreover, there was a significant strong positive correlation between 25-hydroxyvitD and serum calcium.This can be explained by the important role of vitamin D in regulating bone metabolism and bone density.
Finally, there were significant strong negative correlations between 25-hydroxyvitD and fasting blood sugar, HbA1c % indicating that glycemic control is an important factor in maintaining 25-hydroxyvitD around its optimal level.