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العنوان
Ameliorative Effect of Some Antioxidants (Spirulina and Ginseng) on Thiamphenicol Side Effects in Rats /
المؤلف
Metwally, Aya Shawky Mohamed.
هيئة الاعداد
باحث / آية شوقي محمد متولي
مشرف / سوسن محمد على الشيخ
مشرف / حسني عبد الفضيل
مشرف / عبد العليم فؤاد عبد العليم
الموضوع
Thiamphenicol - Adverse effects. Rats.
تاريخ النشر
2016.
عدد الصفحات
168 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
البيطري
تاريخ الإجازة
1/1/2016
مكان الإجازة
جامعة الزقازيق - كلية الطب البيطرى - Department of Veterinary Pharmacology
الفهرس
Only 14 pages are availabe for public view

from 16

from 16

Abstract

Thiamphenicol is a wide spectrum antibiotic used against Gram-positive and Gram-negative bacteria of respiratory, urinary and digestive tract infections. It has received a great interest by researchers due to its importance therapeutic action with a high degree of similarity with chloramphenicol drug. Recently, chloramphenicol is not being used in human and veterinary fields due to its serious side effects. Therefore, it was necessary to search for alternative antibiotics such as thiamphenicol, which have similar therapeutic actions with an attempt to avoid chloramphenicol’s side effects in the tissues. Natural antioxidants such as spirulina and ginseng have proven during the last few decades for its role to protect the vital tissues against oxidative stress and free radicals, resulted from the use of certain medications, particularly antibiotics, through their potential antioxidant activities.
The aim of the current study was to clarify the protective potential of using some antioxidants such as spirulina and/or ginseng against thiamphenicol’s side effects induced by 14 successive day treatment in rats. The experiment was initiated, and the protective potential of the studied antioxidants was performed through the analyses of the complete blood pictures, and some biochemical analysis to illustrate the liver and kidney functions and activity of some enzymes in blood serum.