الفهرس | Only 14 pages are availabe for public view |
Abstract Obesity has assumed pandemic proportions mainly attributable to dietary habits and sedentary lifestyles. More than 1.7 billion adults are overweight and at least 300 million of them are clinically obese (Deitel, 2003). It is a major contributor to the global burden of chronic disease and disability. Often co-existing in the developing countries with under nutrition, obesity is a complex condition, with serious medical, social, psychological, and economical implications, affecting virtually all age groups (World Health Organization, 2000). The comorbidities include type 2 diabetes, cardiovascular disease, hypertension, hyperlipidemia, hypoventilation syndrome, asthma, sleep apnea, stroke, pseudotumorcerebri, arthritis, several types of cancers, urinary incontinence, gallbladder disease, and depression (Fuks et al., 2001). Obesity shortens life expectancy with increasing BMIs, resulting in proportionally shorter lifespan (Moorehead et al., 2003). With over 300,000 victims in the USA each year, morbid obesity is projected to overtake smoking as the leading cause of death in the near future (Braghetto et al., 2007). Non-operative management with diet, exercise, behavior modifications, and medications rarely achieves adequate sustainable weight loss. Surgery is the only proven long-term effective treatment for morbid obesity (Mognol et al., 2005). Laparoscopic sleeve gastrectomy (LSG) gained popularity over the last few years (Strain et al., 2009). Numerous studies have evaluated the effect of Laparoscopic Sleeve gastrectomy on fasting lipids, overall showing beneficial changes such as lowering cholesterol, TGs and LDL-cholesterol and increasing HDL-cholesterol (Lang R et al.,2012)Thirty five patients with morbid obesity (28 female &7males) ranging in age between 20-48 years with BMI range (40.05–72.27) ) kg/m2 were included in the present study. Most of patients were suffered from one or more of obesity related diseases such as (T2DM, HTN, chronic joint pain or hyperlipidemia). All patients had LSG and completed the 2 years follow up period. Those patients were selected according to the preformed inclusion criteria. All patients were subjected to pre and post operative assessment after exclusion of any hormonal imbalance such as hypothyroidism or Cushing syndrome (complete blood count, liver and kidney function tests , fasting and postprandial blood sugar , coagulation profile , ECG , echo-cardiograph , chest X-ray, respiratory functions , abdominal ultrasonography and duplex study of lower limb venous system ). LSG proved to be an effective type of bariatric surgery, this is evidenced in the metabolic and biochemical outcomes following LSG in the form of : Reduction of body weight regarding (% excess weight loss) , improvement of obesity related comorbidities. 80% ,80%,75% of diabetic, hypertensive, and hyperlipidemic patients respectively had improved. in addition to that, all patients of chronic joint pain showed significant improvement after 2 years of LSG. This study confirmed the effect of LSG in treatment of morbid obesity and improving metabolic complications related to it. |