الفهرس 
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Abstract
The present thesis describes the preparation and investigation of performance characteristics of ion-selective electrodes for the antimalarial drug, hydroxychloroquine sulfate. The electrodes are of the polymeric membrane, coated wires electrode, and chemically modified carbon paste types. The active recognition in the electrodes is liquid ion exchange mechanism depending upon ion-exchanger which is ion-associate of the hydroxychloroquine cation [HCQ+] with tetraphenylborate and reineckate incorporated in the membrane.
The thesis comprises three chapters:
Chapter (I); Gives a general introduction on the various electroanalytical techniques and their application. The chapter gives an idea about the different types of chemical electrodes and discusses in detail electrochemical electrodes. It also gives a brief review of the important potentiometric electrodes developed for different drugs.
Chapter (II); Deals with the development of a coated wire electrode for the determination of the drug hydroxychloroquine sulfate (HCQS) based on HCQ-TPB (hydroxychloroquine tetraphenylborate) ion-pair as the electroactive material. The electrochemical response characteristics are described in detail and the application of the developed electrodes in the determination of the drug in pharmaceuticals and urine samples have also been dealt with in detail.
Chapter (III); Presents the fabrication of polymeric membrane and chemically modified carbon paste electrodes for hydroxychloroquine sulfate based on the ion associations of the drug with sodium tetraphenylborate (NaTPB), and ammonium reineckate (NH4Rt) as forming agents. The electrodes exhibited stable, fast Nernstian response over a wide concentration range. The developed electrodes have also been used for the determination of the drug in pharmaceutical preparations and also for the determination of the drug in urine samples.