الفهرس 
Introductionand aim of the workOnly 14 pages are availabe for public view
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Abstract
Background: Thyroid stimulating hormone (TSH), or thyrotropin, is a glycoprotein synthesized and secreted by the thyrotropes of the anterior pituitary gland.It can be influenced by different perinatal factors.
The aim of the present study was to determine the effect of various perinatal factors on cord blood TSH among newborns .
Subjects and methods : This was a descriptive–analytic cross sectional study which performed in Fayoum Governorate.During a period of six months, since May to Octobre 2014 a total number of 150 newborns delivered in Fayoum general and university hospitals were enrolled in the study. For each newborns one mL blood sample from umbilical vein was obtained by one of the project investigators and sent to laboratory for further examinations. Cord blood TSH and birth body weight (BBW), gestational age, history of gestational diabetes mellitus (GDM), apgar at one minute and five minute, newborn gender and the mother’s age were documented. Differences considered statistically significant if P<0.05.
Results: our study reveals 150 newborns enrolled in the study, 73(48.7%) were male and 77(51.3%) were female. Among
study parameters, GDM and PROM had statistically significant relation with cord blood TSH (P<0.001, p=0.01 respectively). There is statistically significant negative association between cord TSH level and 5 minutes Apgar score ( p =0.05)& r= -0.16 and also there is statistically significant negative correlation between cord TSH level and gestational age among preterm babies r= -0.39 & p= 0.04. other factors such as BBW, mode of delivery, apgar at one minute, , newborn gender and the mother’s age didn’t have statistically significant relationship with cord TSH level.
conclusion : we deduce that the factors that can affect cord blood TSH was GDM ,PROM , 5 minutes Apgar score and prematurity . Other factors that were evaluated in this study didn’t have any statistically significant relationship.