الفهرس 
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Abstract
Cyclophosphamide is a chemotherapeutic agent used in treatment of malignancy. Although its great success in treatment of tumors, it initiates a harmful effect on testicular function, thus reducing spermatogenesis and fertility.
The aim of the present work is to study the effect of different doses and different periods of administration of Cyclophosphamide on the testis and spermatogenesis in the adult male albino rat and to evaluate the possible protective role of vitamin E.
Ninety five adult male albino rats were used in the present study. The rats were divided into nine groups. Group I (control group) consisted of 15 rats. The other groups each consisted of 10 rats. Group II : received Cyclophosphamide I.P (70 mg/kg) and sacrificed after16 hours, Group III : received vitamin E (100 mg/kg) orally with Cyclophosphamide (70 mg/kg) I.P and sacrificed after16 hours , Group IV: received Cyclophosphamide (6 mg/kg) I.P once daily for 15 days, Group V: received vitamin E (100 mg/kg) orally with Cyclophosphamide (6 mg/kg) I.P once daily for 15 days), Group VI: received Cyclophosphamide (6 mg/kg) once daily for 30 days, Group VII: received vitamin E (100 mg/kg) with Cyclophosphamide (6 mg/kg) I.P once daily for 30 days, Group VIII: received Cyclophosphamide (6 mg/kg) I.P once daily for 50 days, Group IX: received vitamin E (100 mg/kg) orally with Cyclophosphamide (6 mg/kg) I.P once daily for 50 days.
The animals of each group were sacrificed at the end of the experiment by an overdose of ether and the testes were removed and prepared for histological and histomorphometric study