الفهرس 
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Abstract
Liver has an important role in maintenance performance and regulation of
homostasis of the body because it is the chief site for metabolism and excretion.
Maintaining a healthy liver is an important factor to maintain the overall health
although the liver is exposed to complex mixtures of toxic compounds everyday,
particularly pesticides.
While performing pesticide detoxifications, liver undergoes oxidative
stress, leading to several health hazards including liver damage which might be
followed by impairment of brain function or lung function.
The potential mechanisms of pesticides induced-toxicity may be through
free radicals which may contribute to loss of enzymatic activity, structural cells
integrity, alteration in lipids, proteins and DNA content in the cell as well as
inhibition of AChE activity and alteration in nerve conduction.
Since synthetic drugs used in treatment of liver diseases have serious
adverse effects, search of effective, safe, cheap, readily available and contain
many anti-oxidant compounds nutraceuticals could be a preferred alternative
solution to the chemically synthesized drugs, avoiding their various side effects;
so this study aimed at the following:
1. Studying the prevalence of hepatic encephalopathy syndrome and its
precipitating factors in a sample of cirrhotic patients admitted at Tropical
Medicine Department and Hepatology Intensive Care Unit (HICU) of
Zagazig University Hospitals along one year duration.
2. Identifying phytochemical compounds of physalis and punica quantitatively
and qualitatively in-vitro to investigate their anti-oxidant activity.3. Evaluating the consequences of oral exposure to an organophsphorus
pesticide (fenitrothion) for 42 consecutive days on liver function and its
possible deleterious action on brain and lung function in rats.
4. Investigating the possible prophylactic and curative effects of physalis,
punica and silymarin (standard drug) against liver damage induced by
fenitrothion and its expected complications on brain and lung function.