الفهرس 
PART I: General IntroductionOnly 14 pages are availabe for public view
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Abstract
This thesis is devoted to the development of new methods for the analysis of certain drugs used in the treatment of respiratory tract disorders, namely: Formoterol Fumarate (FF), Budesonide (BUD), and Indacaterol Maleate (IND) in pure form and in pharmaceutical preparations. A simple and rapid IPC method with UV detection was developed for simultaneous determination of binary mixture; Formoterol Fumarate and Budesonide in their raw materials as well as metered dose inhaler without pre-column derivatization or gradient elution.Two simple, sensitive and reliable spectrophotometric and spectrofluorimetric methods were developed for the determination of Indacaterol. The methods depend on measurement of the absorbance and the native fluorescence of the drug for methods I and II, respectively. The two methods could be successfully applied to the determination of IND in capsule dosage form. The method was further applied to content uniformity testing according to USP guidelines. Stability indicating study was applied to method I.A sensitive and specific reversed-phase liquid chromatographic method with ultraviolet and fluorescence detection was developed for determination of IND in raw material. Different chromatographic parameters were investigated and the methods were successfully applied for the determination of IND in pure form and in its capsule formulations.Three simple, sensitive, and reliable spectrophotometric methods were developed for the determination of IND. Difference spectrophotometric method was established for determination of IND in method A. Methods B and C briefly performed by the reaction of IND with two different reagents namely MBTH and 4-AAP. The three methods could be successfully applied to the determination of IND in capsule dosage forms.