الفهرس 
cover EnglishOnly 14 pages are availabe for public view
 |  | from | 139 |  |  |
| | | from | 139 | | |
Abstract
Research and development of silver nanoparticles technology are currently among the fastest growing areas in nanosciences due to the wide range of applications from photographic films to bactericides. For most of these technological applications, physically and chemically stabilized silver nanoparticles are required. Also, the control of the size, shape and composition lead to total change in the properties of the nanoparticles. One of the main goals of this thesis is to achieve control over the size and shape of silver nanoparticles and to study the factors which could affect the size and shape of the formed particles such as temperature, concentration, type of capping materials. In addition, new methodology have been developed to prepare nanocomposites of cobalt- silver and magnetite-silver hybrid nanocomposites The optical and magnetic properties of these nanocomposites were studied. These systems are so promising for Cancer therapy and imaging due to the photothermal effect of the silver nanoshell and the magnetic properties of the cobalt core. The magnetic properties of this hybrid structure made them wonderful candidate for Cancer diagnosis using MRl. By irradiation with visible light, the silver absorb light strongly due to Plasmon resonance, then this light is transferred efficiently into heat due to irradiative processes (heat dispassion to the surrounding). The photostability of the formed particles has been studied using different light sources such as UV lamp and Light Emitting Diode (LED). It has been found that irradiation with light change the particle morphology and affect the particle stability. Studying the potential application of these nanoparticles on cancer treatment showed high efficiency on HEp-2 laryngeal carcinoma cell line viability reduction. Silver (Ag) and magnetite Isilver (Fe30JAg ) nanocomposites incubation with HEp-2 cells for 5 hours and exposure to Light Emitting Diode (LED) 490 nm energy of 200 J caused nearly the same effect on the HEp-2 cell viability (90% mortality) for both types, cobalt /silver (CoIAg) nanocomposites show the highest efficiency against HEp-2 cells. At very low concentration, light energy 0.05 mM, 72 J respectively. It causes 100٪ mortality of the HEp-2 cells. The experimental conditions such as concentration of the particles, light dose, time of exposure which caused the best efficiency of laryngeal cancer cells viability reduction have been studied.