الفهرس 
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Abstract
Androgenetic alopecia (AGA) is an androgen induced disorder that
is characterised by hair loss in genetically predisposed men and women.
It requires adequate androgens to be in circulation and a genetic
predisposition. In AGA, androgens induce miniaturisation in follicles that
are genetically predisposed to baldness. Such miniaturisation is observed
in the frontotemporal area and vertex in men, and over the crown in
women, as these areas are more sensitive to the effects of androgens.
Various studies have demonstrated that AGA can have a significant
negative impact on the quality of life of the affected persons. For women
affected with AGA the main factors contributing to psychological distress
were : inability to style their hair, dissatisfaction with their appearance,
concern about the continuing hair loss and concern about others noticing
their hair loss .
The disease onset and progression vary from person to person.
Initial signs of male AGA usually develop during teenage years, leading
to progressive hair loss with pattern distribution. Bitemporal hair loss
starts at the anterior hair line, resulting in a receding hair line followed by
hair loss over the vertex and mid-frontal areas, with sparing of the
occipital scalp .
In women, AGA typically presents as a diffuse reduction in hair
density over the frontal and central areas, but the parietal and occipital
regions may also be involved .
Dyslipidemia is the disorder of lipoprotein metabolism, including
lipoprotein overproduction or deficiency that may be in the form of
elevation of the total cholesterol, the low-density lipoprotein (LDL) and
Summary and Conclusion
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the triglyceride concentrations, and a decrease in the ”good” high-density
lipoprotein (HDL) concentration in the blood.
Dyslipidemia is one of the most important risk factors for coronary
heart diseases.The relationship between lipid profile and CHD has been
analysed in several studies but The mechanism of the association of CHD
and AGA has not been elucidated.
The pathogenetic mechanisms of atherosclerosis are quite well
known, but the pathogenetic link between androgenetic alopecia and
atherosclerosis is not clear. Higher cholesterol and trigyceride levels
participate along with other mechanisms in initiating atherosclerosis .
HDL on the other hand protects the vascular wall from aggressive factors
and facilitates the reverse transport of cholesterol. The unfavourable lipid
profile in men and women with AGA could explain its association with
CHD.
The aim of this work is to analyze the prevalence of dyslipidemia
in men and women with androgenic alopecia .
This case-control study included 150 participants ; 100 (40 males
and 60 females) patients of AGA of Ludwig scales (degree II or above
for females) and of ebling scale (degree III or above for males ”vertex
and frontal alopecia”) and 50 controls (17 males and 33
females).consecutively admitted to the outpatient clinic (Dermatology
and andrology Department, Benha University ), The control group
presented skin diseases other than alopecia. All studied individuals were
subjected to history taking and clinical examination. Lipid profile
parameters were assessed in this work ,which are serum
cholesterol,serum triglyceride ,serum LDL and serum HDL.
Summary and Conclusion
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The result of this work showed the following
1.In all patients with AGA, serum levels of cholesterol and TG were
found to be significantly higher than controls ,While HDL was
significantly lower than controls.
2. Male patients with AGA were found to have significantly higher serum
levels of serum TG.
3.Female patients with AGA were found to have significantly higher
levels of serum TG and cholesterol, while HDL ”the protective
cholesterol ” were found to be significantly lower in female patients with
AGA.
4.A high statistically significant positive correlation between degree of
androgenetic alopecia in male and female cases and both age and onset of
the disease i.e the earlier the onset of androgenetic alopecia , the more the
degree of AGA.
5. there was a positive non significant correlation among degree of
androgenetic alopecia in male patients and serum cholesterol and serum
TG .
6.Female patients with AGA were found to be more susceptible to
dyslipidemia than males with AGA as females had higher serum
cholesterol, serum triglycerides and serum LDL levels than male patients
, in addition to the lower serum HDL levels which is the protective
cholesterol . This was inspite of the lower mean age of female patients
( 29.15±8.29 years) in comparison to male patients (36.77±8.95 years).
Summary and Conclusion
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Conclusion
Dyslipidemia is highly prevalent in patients with AGA. This study
provides support for recommending the assessment of lipid profile in all
males with grade III or higher AGA,according to the Hamilton–Norwood
classification or alopecia ≥ grade II in Ludwig’s classification for
females.
Female patients with AGA may be more susceptible to
dyslipidemia than males with AGA.