الفهرس 
List of abbreviationsOnly 14 pages are availabe for public view
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Abstract
Patients with ESRD are frequently burdened with calcific valvular heart disease. Valvular involvement in ESRD is most commonly manifested as mitral annular calcification and aortic valve calcification. Both mitral and aortic valve calcification (MAC) occur more frequently and at younger age in those with ESRD than in those with normal renal function.
The aim of this study was to determine the frequency of aortic and mitral valves calcifications in haemodialysis patients using echocardiography. The frequency of valvular calcifications in hemodialysis patients was studied in 50 patients on regular hemodialysis in Bani Suif university hospital. Evaluation included serum assays and echocardiography.
Valvular calcifications was highly prevalent in our HD patients, it was detected in 32 patients (62 %), 21 patients (65.62 %) had isolated aortic calcification, while 11 patients (34.37 %) had both aortic and mitral calcification. None had neither pulmonary nor tricuspid valve calcification.
In comparison to patients without valvular calcification , HD patients with valvular calcification were older in age , with a longer HD duration , showed higher P level and CaxP product indicating that these factors may be responsible for the development of valvular calcification also they showed lower EF % and were on larger doses of Calcium and Alphacalcidol . On the other hand our study showed no association between serum calcium and PTH with valvular calcification.
Compared with HD patients with isolated aortic valve calcification , patients with both aortic and mitral cardiac valve calcification had longer time on dialysis lower serum calcium ,
higher serum phosphorus, higher CaxP product and were on larger doses of calcium carbonate the difference between both groups was significant. There were no significant differences between both groups regarding levels of serum urea, creatinine, albumin, PTH, all echocardiographic data and Alphacalcidol dose .
In a multiple regression model, age, longer dialysis duration and CaxP product were positively correlated with valvular calcification but EF % was negatively correlated with valvular calcification.
Echocardiography is an easy, non-invasive method that can be reliably used to assess valvular calcification.
Knowledge of modifiable risk factors can help to control valvular calcification in HD patients.